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Our genetic testing reveals susceptibility to concussions

Genetics play an immense roll in the likelihood of sustaining a concussion and the protocol to help recover from a concussion.  Genetic testing is one component to keeping athletes safe and on the field.

If the gene is identified, we create a plan to enhance the brain creating internal protection.

To learn more click on research links below:

Role of Genetic Factors in Concussion Risk and Outcome

http://iom.nationalacademies.org/~/media/Files/Activity%20Files/Children/Sports-Related-Concussion/Tom%20McAllister.pdf

Apolipoprotein E genotype and concussion in college athletes.

http://www.ncbi.nlm.nih.gov/pubmed/21079443

What APOE Means for Your Health

http://www.alzdiscovery.org/cognitive-vitality/what-apoe-means-for-your-health

Clin J Sport Med. 2010 Nov;20(6):464-8. doi: 10.1097/JSM.0b013e3181fc0a81.

Apolipoprotein E genotype and concussion in college athletes.

Abstract

OBJECTIVE:

To evaluate the association between apolipoprotein E (APOE) polymorphisms (E2, C/T Arg158Cys; E4, T/C Cys112Arg; and promoter, g-219t) and the history of concussion in college athletes. We hypothesized that carrying 1 or more APOE rare (or minor) allele assessed in this study would be associated with having a history of 1 or more concussions.

DESIGN:

Multicenter cross-sectional study.

SETTING:

University athletic facilities.

PARTICIPANTS:

One hundred ninety-six male football (n = 163) and female soccer (n = 33) college athletes volunteered.

INTERVENTIONS:

Written concussion history questionnaire and saliva samples for genotyping.

MAIN OUTCOME MEASURES:

Self-reported history of a documented concussion and rare APOE genotype (E2, E4, promoter).

RESULTS:

There was a significant association (Wald χ² = 3.82; P = 0.05; odds ratio = 9.8) between carrying all APOE rare alleles and the history of a previous concussion. There was also a significant association (Wald χ² = 3.96, P = 0.04, odds ratio = 8.4) between carrying the APOE promoter minor allele and experiencing 2 or more concussions.

CONCLUSIONS:

Carriers of all 3 APOE rare (or minor) alleles assessed in this study were nearly 10 times more likely to report a previous concussion and may be at a greater risk of concussion versus noncarriers. Promoter minor allele carriers were 8.4 times more likely to report multiple concussions and may be at a greater risk of multiple concussions versus noncarriers. Research involving larger samples of individuals with multiple concussions and carriers of multiple APOE rare alleles is warranted.

http://www.ncbi.nlm.nih.gov/pubmed/21079443